The Canadian Open Parkinson Network (C-OPN) provides an invaluable resource for advancing Parkinson’s disease research. Below are some innovative projects that have leveraged C-OPN’s comprehensive dataset.
| Request Number | Request Type | Researcher Name (Requester) | Principal Investigator (if applicable) | Institution/Organization | Project Title |
|---|---|---|---|---|---|
| 1 | Data | Helena Denis | Dr. Francesca Cicchetti | CHUQ | Les vésicules extracellulaires dérivées d'érythrocyte: biomarqueurs de la maladie de Parkinson |
| 2 | Data | Dr. Juan Li | Dr. Michael Schlossmacher | Ottawa Hospital Research Institute (OHRI)/ University of Ottawa | Validation of the PREDIGT Score for the Incidence of Parkinson's Disease compared to Healthy Subjects |
| 3 | Data | Dr. Iris Kathol | Dr. Oury Monchi | University of Calgary | PD-MBI-GEN |
| 4 | Data | Ibukun Ojo | Dr. Fang Ba and Dr. Myasaki | University of Alberta | Ethnic and Gender Disparities in Access to Deep Brain Stimulation Surgery |
| 5 | Data | Dr. James McVittie | Dr. James McVittie | University of Regina | Improve survival analysis methodologies for combining different types of cohort data and modelling measurement error in reported dates of onset of disease |
| 6 | Data and Material | GP2 Team | Dr. Andrew Singleton | NIH | C-OPN & Global Parkinson’s Genetics Program (GP2) |
| 7 | Data and Material | Dr. Aarnoud van der Spoel | Dr. Aarnoud van der Spoel | Dalhousie University | Improve survival analysis methodologies for combining different types of cohort data and modelling measurement error in re+[@[Project Title]]ported dates of onset of disease |
| 8 | Data and Material | Meron Teferra | Dr. Ziv Gan-Or | McGill University | The genetics of REM sleep behavior disorder, Parkinson’s disease and other synucleinopathies |
| 9 | Data and Material | Catherine Dery | Dr. Nicolas Dupré and Dr. Manon Bouchard | CHU de Québec - Université Laval Research Centre | Association between levodopa-carbidopa dose, plasma vitamin B6 deficiency and polyneuropathy in patients with a parkinsonian syndrome: data from the Canadian Open Parkinson Network |
| 10 | Data | Dr. Aurélie de Rus Jacquet; C-OPN Team | Dr. Francesca Cicchetti | CHUQ | Clinical perception and management of Parkinson's disease during the COVID-19 pandemic: A Canadian experience |
| 11 | Registry | Zi Hui (Lily) Su Zi Su | Dr. Chrystalina Antoniades | Oxford University | Online population study on time perception in Parkinson's disease and aged population |
| 12 | Registry | Pénélope Bernier | Dr. Pierre-Yves Therriault | Université du Québec à Trois-Rivières | L’utilisation de la domotique en ergothérapie : perception d’utilisateurs atteints de la maladie de Parkinson |
| 13 | Registry | Petra Uzelman | Dr. Silke Cresswell | University of British Columbia | Treating anxiety in Parkinson’s disease with a multi-strain probiotic – a randomized, placebo-controlled trial |
| 14 | Registry | Dr. Madeleine Sharp | Dr. Madeleine Sharp | McGill Univeristy | Deep cognitive endophenotyping of Parkinson’s disease: A platform development and pilot study. |
| 15 | Registry | Dr. Ryan D'Arcy | Dr. Ryan D'Arcy | University of British Columbia | Multimodal neuromodulation in individuals with Parkinson's Disease |
| 16 | Registry | Dr. Tejas Sankar | Dr. Tejas Sankar | University of Alberta | Changes in spinal reflexes used post-operatively as a biomarker for optimized treatment from deep brain stimulation in Parkinson's disease |
| 17 | Registry | Dr. Richard Camicioli and Dr. Kelvin Jones | Dr. Richard Camicioli and Dr. Kelvin Jones | University of Alberta | Study in Parkinson Disease of Exercise Phase 3 Clinical Trial: SPARX3 |
| 18 | Registry | Dr. Ayse Kuspinar | Dr. Ayse Kuspinar | McMaster University | Development of a new health-related quality of life measure for Parkinson’s disease |
| 19 | Registry | Dr. Penny MacDonald | Dr. Penny MacDonald | University of Western | Establishing definitive MRI diagnostic testing of Parkinson's disease |
| 20 | Registry | Dr. Martin McKeown | Dr. Martin McKeown | University of British Columbia | Development of a new health-related quality of life measure for Parkinson’s disease |
| 21 | Registry | Dr. Kathryn Lambert | Dr. Ada Leung | University of Alberta | Examining the contribution of executive functions to motor imagery ability in people with Parkinson's disease and healthy older adults |
| 22 | Data | Dr. Lorraine Kalia | Dr Kalia Lorraine | Toronto Western Hospital: University Health Network (UHN) | Cultural Considerations in Daily Levodopa Equivalent Dosage: A Study of Global Population |
| 23 | Data and Material | PhD Nikhil Parag Bhagwat | PhD Nikhil Parag Bhagwat | McGill University | Quebec Parkinson Network cohort: A standardized and preprocessed neuroimaging and clinical dataset for PD biomarker discovery |
| 24 | Data | Dr Aurélie de Rus Jacquet | Dr Aurélie de Rus Jacquet | Centre de recherche du CHU de Québec-Université Laval | Parkinson's Disease in Quebec: Mapping Project |
| 25 | Data and Material | Mathieu Blais | Dr Nicolas Dupré | CHU de Québec – Université Laval | Étude épidémiologique et génétique de la maladie de Parkinson au Québec |
| 26 | Data | Gabriel David Pinilla | Dr Oury Monchi | Centre de recherche de l'IUGM Université de Montréal (Quebec) | C-OPN Cohort Genetic Profile |
| 27 | Data | Cristiane Ribeiro Chaves | Cristiane Ribeiro Chaves | Laboratoire de recherche en audition et vieillissement - CRIUGM | Maladie de Parkinson et ses répercussions sur la voix, la participation sociale et la qualité de vie |
| 28 | Data | Alavash Mohshen | Prof. Dr. med. Thomas Münte | University of Lübeck | Studying brain resting-state neural dynamics in Parkinson disease using MEG and their relation to clinical outcomes |
| 29 | Data | Nicolas Ferry | Dr Aurélie de Rus Jacquet | Centre de recherche du CHU de Québec-Université Laval | C-OPN PBMC analysis |
| 30 | Data and Material | Aymeric Lanore | Dr Jean-Christophe Corvol | Paris Brain Institute | PRECISE-PD & C-OPN Collaboration |
| 31 | Data | Gail Dimapilis | Dr Fang Ba | University of Alberta | Ethnic and Gender Disparities in Access to Deep Brain Stimulation Surgery for Movement Disorders. |
| 32 | Data | Dr Aurélie de Rus Jacquet | Dr Aurélie de Rus Jacquet | Centre de recherche du CHU de Québec-Université Laval | Reprogramming C-OPN's Indigenous PBMCs into iPSCs |
| 33 | Data | Dr. Catalina Cerquera Cleves | Dr. Catalina Cerquera Cleves | CHU de Québec – Université Laval | 2nd cohort Manuscript |
| 34 | Registry | Dr. Judith Bek | Dr. Judith Bek | University of Toronto | Dancing with the mind and body: Exploring strategies for movement through dance in Parkinson’s |
| 35 | Registry | Caitlin Kelliher | MJFF | MJ Fox Foundation | Parkinson's Progression Markers Initiative (PPMI) |
| 36 | Registry | Dr. Madeleine Sharp | Dr. Madeleine Sharp | McGill Univeristy | Patient Attitudes about Clinical Trial Participation |
| 37 | Registry | Yuko Koshimori | Dr. Michael Thaut | University of Toronto | Does motor synchronization to Rhythmic Auditory Stimulation (RAS) alter dopamine responses in Parkinson’s disease? |
| 38 | Registry | Waad AlOlayan | Dr. Jana Rieger | University of Alberta | Technology for Swallowing Exercises in Parkinson's Disease: A Usability Study |
| 39 | Data | Hailu, Ambachew | Dena Hernandez | NIH | NIH Genotyping Experiment |
| 40 | Material | Zaid Al Azzawi | Dr. Ted Fon | McGill University | Biochemical and pathological characterization of synuclein aggregates from PD and RBD patient plasma |
| 41 | Data | Dr. Alain Dagher | Dr. Alain Dagher | McGill University | Ethnicity data contributed to NIH grant application |
| 42 | Material | Shawna Reddie | Dr. David Grimes | Ottawa Hospital Research Institute | Study on Parkinson's disease in patients with GBA mutation |
| 43 | Data | Dr. Silke Cresswell | Dr. Silke Cresswell | University of British Columbia | Information on Early PD among C-OPN cohort |
| 44 | Data | Dr. James McVittie | Dr. James McVittie | University of Regina | Developing a procedure to estimate the unknown parameters in a proportional hazards model using current lifetime data |
| 45 | Data and Material | Dr. Davide Martino | Dr. Davide Martino | University of Calgary | C-OPN CAPRI LRRK2 mutations participant list |
| 46 | Data and Material | Madeleine Powell | Dr. Jon Stoessl | University of British Columbia | C-OPN UBC GBA mutations participant list |
| 47 | Data | Lietsel Jones | GP2 Initiative | GP2 | Updated of C-OPN GP2 Clinical Data |
| 48 | Data | Le Xing | Dr. Zhiying Long | Beijing Normal University | Study on Brain Dynamics in Parkinson's Disease Using MEG Data |
| 49 | Data | Mathieu Blais | Dr. Catalina Cerquera Cleves | CHUQ - ULaval | Exploring the relationship between diabetes and symptom severity in PD |
| 50 | Data | Hamzeh Norouzi (PhD) | Hamzeh Norouzi (PhD) | University of Stirling | Validating article by QPN: "Structural and neurophysiological alterations in Parkinson’s disease are aligned with cortical neurochemical systems |
| 51 | Data | Andrew Vo | Dr. Nikhil Parag Bhagwat | McGill University | Update on Quebec Parkinson Network cohort: A standardized and preprocessed neuroimaging and clinical dataset for PD biomarker discovery |
| 52 | Data | Muhammad Faran | Muhammad Faran | Vancouver Fraser Medical Program | Cohort study of individuals not receiving DBS vs receiving DBS on non motor symptoms. |
| 53 | Registry | Pamela Harrison and Caitlin Kelliher | MJFF | MJ Fox Foundation | Parkinson's Progression Markers Initiative (PPMI) - Phase II |
| 54 | Registry | Neil Boyt | Dr. Aileen Ho | University of Reading, UK | Brief Exercise in Guided and Reflective Writing for PD Study |
| 55 | Registry | Nisha Pulimood | Dr. Ron Postuma | McGill Univeristy | A multi-site longitudinal cohort study of Prodromal and Clinical PD |
| 56 | Registry | Stéphanie Lavigne | Dr. Michal Thaut | University of Toronto | Functional Brain Networks of Auditory-Motor Synchronization in Healthy adults and in adults with PD |
These projects exemplify the diverse and impactful research enabled by the C-OPN, driving forward our understanding and treatment of Parkinson’s disease.
