The Canada Open Parkinson Network (C-OPN) provides an invaluable resource for advancing Parkinson’s disease research. Below are some innovative projects that have leveraged C-OPN’s comprehensive dataset.
| Type | Researcher | PI | Institution affiliated with NIH | Project Title |
|---|---|---|---|---|
| Data | Helena Denis | Dr. Francesca Cicchetti | CHUQ | Les vésicules extracellulaires dérivées d'érythrocyte: biomarqueurs de la maladie de Parkinson |
| Data | Dr. Juan Li | Dr. Michael Schlossmacher | Ottawa Hospital Research Institute (OHRI)/ University of Ottawa | Validation of the PREDIGT Score for the Incidence of Parkinson's Disease compared to Healthy Subjects |
| Data | Dr. Iris Kathol | Dr. Oury Monchi | University of Calgary | PD-MBI-GEN |
| Data | Ibukun Ojo | Dr. Fang Ba and Dr. Myasaki | University of Alberta | Ethnic and Gender Disparities in Access to Deep Brain Stimulation Surgery |
| Data | Dr. James McVittie | Dr. James McVittie | University of Regina | Improve survival analysis methodologies for combining different types of cohort data and modelling measurement error in reported dates of onset of disease |
| Data and Material | GP2 Team | Dr. Andrew Singleton | NIH | C-OPN & Global Parkinson’s Genetics Program (GP2) |
| Data and Material | Dr. Aarnoud van der Spoel | Dr. Aarnoud van der Spoel | Dalhousie University | Improve survival analysis methodologies for combining different types of cohort data and modelling measurement error in re+[@[Project Title]]ported dates of onset of disease |
| Data and Material | Meron Teferra | Dr. Ziv Gan-Or | McGill University | The genetics of REM sleep behavior disorder, Parkinson’s disease and other synucleinopathies |
| Data and Material | Catherine Dery | Dr. Nicolas Dupré and Dr. Manon Bouchard | CHU de Québec - Université Laval Research Centre | Association between levodopa-carbidopa dose, plasma vitamin B6 deficiency and polyneuropathy in patients with a parkinsonian syndrome: data from the Canadian Open Parkinson Network |
| Data | Dr. Aurélie de Rus Jacquet; C-OPN Team | Dr. Francesca Cicchetti | CHUQ | Clinical perception and management of Parkinson's disease during the COVID-19 pandemic: A Canadian experience |
| Registry | Zi Hui (Lily) Su Zi Su | Dr. Chrystalina Antoniades | Oxford University | Online population study on time perception in Parkinson's disease and aged population |
| Registry | Pénélope Bernier | Dr. Pierre-Yves Therriault | Université du Québec à Trois-Rivières | L’utilisation de la domotique en ergothérapie : perception d’utilisateurs atteints de la maladie de Parkinson |
| Registry | Petra Uzelman | Dr. Silke Cresswell | University of British Columbia | Treating anxiety in Parkinson’s disease with a multi-strain probiotic – a randomized, placebo-controlled trial |
| Registry | Dr. Madeleine Sharp | Dr. Madeleine Sharp | McGill Univeristy | Deep cognitive endophenotyping of Parkinson’s disease: A platform development and pilot study. |
| Registry | Dr. Ryan D'Arcy | Dr. Ryan D'Arcy | University of British Columbia | Multimodal neuromodulation in individuals with Parkinson's Disease |
| Registry | Dr. Tejas Sankar | Dr. Tejas Sankar | University of Alberta | Changes in spinal reflexes used post-operatively as a biomarker for optimized treatment from deep brain stimulation in Parkinson's disease |
| Registry | Dr. Richard Camicioli and Dr. Kelvin Jones | Dr. Richard Camicioli and Dr. Kelvin Jones | University of Alberta | Study in Parkinson Disease of Exercise Phase 3 Clinical Trial: SPARX3 |
| Registry | Dr. Ayse Kuspinar | Dr. Ayse Kuspinar | McMaster University | Development of a new health-related quality of life measure for Parkinson’s disease |
| Registry | Dr. Penny MacDonald | Dr. Penny MacDonald | University of Western | Establishing definitive MRI diagnostic testing of Parkinson's disease |
| Registry | Dr. Martin McKeown | Dr. Martin McKeown | University of British Columbia | Development of a new health-related quality of life measure for Parkinson’s disease |
| Registry | Dr. Kathryn Lambert | Dr. Ada Leung | University of Alberta | Examining the contribution of executive functions to motor imagery ability in people with Parkinson's disease and healthy older adults |
| Data | Dr. Lorraine Kalia | Dr Kalia Lorraine | Toronto Western Hospital: University Health Network (UHN) | Cultural Considerations in Daily Levodopa Equivalent Dosage: A Study of Global Population |
| Data and Material | PhD Nikhil Parag Bhagwat | PhD Nikhil Parag Bhagwat | McGill University | Quebec Parkinson Network cohort: A standardized and preprocessed neuroimaging and clinical dataset for PD biomarker discovery |
| Data | Dr Aurélie de Rus Jacquet | Dr Aurélie de Rus Jacquet | Centre de recherche du CHU de Québec-Université Laval | Parkinson's Disease in Quebec: Mapping Project |
| Data and Material | Mathieu Blais | Dr Nicolas Dupré | CHU de Québec – Université Laval | Étude épidémiologique et génétique de la maladie de Parkinson au Québec |
| Data | Gabriel David Pinilla | Dr Oury Monchi | Centre de recherche de l'IUGM Université de Montréal (Quebec) | C-OPN Cohort Genetic Profile |
| Data | Cristiane Ribeiro Chaves | Cristiane Ribeiro Chaves | Laboratoire de recherche en audition et vieillissement - CRIUGM | Maladie de Parkinson et ses répercussions sur la voix, la participation sociale et la qualité de vie |
| Data | Alavash Mohshen | Prof. Dr. med. Thomas Münte | University of Lübeck | Studying brain resting-state neural dynamics in Parkinson disease using MEG and their relation to clinical outcomes |
| Data | Nicolas Ferry | Dr Aurélie de Rus Jacquet | Centre de recherche du CHU de Québec-Université Laval | C-OPN PBMC analysis |
| Data and Material | Aymeric Lanore | Dr Jean-Christophe Corvol | Paris Brain Institute | PRECISE-PD & C-OPN Collaboration |
| Data | Gail Dimapilis | Dr Fang Ba | University of Alberta | Ethnic and Gender Disparities in Access to Deep Brain Stimulation Surgery for Movement Disorders. |
| Data | Dr Aurélie de Rus Jacquet | Dr Aurélie de Rus Jacquet | Centre de recherche du CHU de Québec-Université Laval | Reprogramming C-OPN's Indigenous PBMCs into iPSCs |
| Data | Dr. Catalina Cerquera Cleves | Dr. Catalina Cerquera Cleves | CHU de Québec – Université Laval | 2nd cohort Manuscript |
| Registry | Dr. Judith Bek | Dr. Judith Bek | University of Toronto | Dancing with the mind and body: Exploring strategies for movement through dance in Parkinson’s |
| Registry | Caitlin Kelliher | MJFF | MJ Fox Foundation | Parkinson's Progression Markers Initiative (PPMI) |
| Registry | Dr. Madeleine Sharp | Dr. Madeleine Sharp | McGill Univeristy | Patient Attitudes about Clinical Trial Participation |
| Registry | Yuko Koshimori | Dr. Michael Thaut | University of Toronto | Does motor synchronization to Rhythmic Auditory Stimulation (RAS) alter dopamine responses in Parkinson’s disease? |
| Registry | Waad AlOlayan | Dr. Jana Rieger | University of Alberta | Technology for Swallowing Exercises in Parkinson's Disease: A Usability Study |
| Data | Hailu, Ambachew | Dena Hernandez | NIH | NIH Genotyping Experiment |
| Material | Zaid Al Azzawi | Dr. Ted Fon | McGill University | Biochemical and pathological characterization of synuclein aggregates from PD and RBD patient plasma |
| Data | Dr. Alain Dagher | Dr. Alain Dagher | McGill University | Ethnicity data contributed to NIH grant application |
| Material | Shawna Reddie | Dr. David Grimes | Ottawa Hospital Research Institute | Study on Parkinson's disease in patients with GBA mutation |
| Data | Le Xing | Dr. Zhiying Long | Beijing University | Study on Brain Dynamics in Parkinson's Disease Using MEG Data |
| Data | Mathieu Blais | Dr. Catalina Cerquera Cleves | Centre de recherche du CHU de Québec-Université Laval | Testing specific hypothesis for manuscript |
These projects exemplify the diverse and impactful research enabled by the C-OPN, driving forward our understanding and treatment of Parkinson’s disease.
